The Brain: Alzheimer's and dementia news and discussions

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weatheriscool
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Simple molecule shows remarkable Alzheimer's reversal in rats ScienceDaily
https://www.sciencedaily.com/releases/2 ... 220052.htm
"A low-cost, copper-targeting molecule from Brazil may offer a powerful new way to combat Alzheimer’s.
Date:
November 19, 2025
Source:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Summary:
Scientists have developed a new molecule that breaks down beta-amyloid plaques by binding to excess copper in the brain. The treatment restored memory and reduced inflammation in rats, while also proving non-toxic and able to cross the blood–brain barrier. Because it’s far simpler and potentially cheaper than existing drugs, researchers are now pursuing partnerships to begin human trials.
"
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New possible treatment pathway for Shank3-related autism discovered
https://medicalxpress.com/news/2025-11- ... utism.html
by Ingrid Fadelli, Medical Xpress
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by differences in communication, behavior and the processing of sensory information. Past research has shown that some individuals diagnosed with ASD exhibit specific genetic variants or differences in the regulation of genes.

In some patients, the Shank3 gene was found to be mutated, partially or fully deleted, or not expressed as much. This gene is known to support the creation of junctions at which connected neurons communicate with each other, known as synapses.

Past findings suggest that people diagnosed with ASD who exhibit variants in Shank3 also present abnormalities in the volume, structure and function of white matter. White matter is a brain region filled with a fatty substance known as myelin, which insulates nerves and allows signals to travel faster within the nervous system.
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Shingles vaccine shows surprising link to lower dementia risk
Sanjana Gajbhiye
https://www.earth.com/news/shingles-vac ... um=twitter
Public-health decisions sometimes create natural experiments that reveal things no lab could plan. Wales unintentionally produced one of those moments when a routine shingles vaccine – given only to people hitting a very narrow age window – appeared to protect long-term memory.

The unexpected pattern caught the attention of Stanford Medicine researchers, who combed through years of medical records and found something striking.

A follow-up study deepened the story, pointing toward viral reactivation, immune aging, and neuroinflammation as powerful – and often overlooked – forces in cognitive decline.

Together, the findings suggest that a simple shingles shot may do far more for the aging brain than anyone expected.
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Cancer tumors may protect against Alzheimer's by cleaning out protein clumps

https://medicalxpress.com/news/2026-01- ... lumps.html
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One-third of dementia cases are linked to non brain-related diseases, study finds

https://medicalxpress.com/news/2026-02- ... eases.html
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Cannabis Compound Shows Promise in Fighting Alzheimer’s by Calming Brain Inflammation

https://scitechdaily.com/cannabis-compo ... lammation/
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