Aging & Longevity News and Discussions

[Ken_J]

please don't give Free staters a lick of attention.

[weatheriscool]

Common supplement shows new signs of interrupting the aging process
By Bronwyn Thompson
February 04, 2025
https://newatlas.com/aging/omega-3-aging/

While the price of eggs in the US is unlikely to come down anytime soon, it might be time to find other sources of one of their key nutrients – omega-3. Because the latest research on polyunsaturated fatty acid (PUFA) has found some encouraging signs that it can slow the aging process.

An international team of researchers, including scientists from Australia's Monash University and Switzerland's University of Zurich, have reported that, for people aged 70 or over, omega-3 may press pause on cellular aging. In a three-year study of 777 individuals from five European countries, the team found that PUFA stalled the ticking of time, biologically speaking. While this translated to around 2.9-3.8 months over the three years, it's a promising result for maintaining healthy aging.

The comprehensive study tested eight treatments divided among the 777 adults, with different combinations of omega-3, vitamin D and exercise (three times a week for 30 minutes). The researchers found that blood samples upon completion of the study showed a significant difference in the samples of those who were prescribed the omega-3, vitamin D and exercise program, while there was improvement in the groups that had the PUFA included, as opposed to those with just vitamin D.

[firestar464]

Inducing prolonged torpor-like state in mice slows epigenetic changes that accompany aging

https://medicalxpress.com/news/2025-03- ... netic.html

[firestar464]

[wjfox]

World’s Second-Oldest Person, Ethel Caterham, 115, Becomes UK’s Oldest Person Ever

Posted by Ben Hinchliffe | Apr 7, 2025 | News

LongeviQuest is pleased to confirm that the oldest living person in Europe and second-oldest person in the world, Ethel Caterham, has become the oldest ever British person upon reaching the age of 115 years and 229 days. Mrs. Caterham set the new British longevity record on 7th April upon surpassing the age of Charlotte Hughes (1877–1993), a record that has stood for 33 years.

Caterham was born in Shipton Bellinger, Hampshire, England on 21st August 1909 and grew up in Wiltshire. In 1927, at the age of 18, she found work as a nanny for a British family living in India, travelling independently by ship for three weeks to start her new role — a rare adventure for a young woman at the time.

She returned to England three years later and in 1931 met her future husband Norman, a major in the British army, at a dinner party. The couple married in Salisbury Cathedral before moving to Gibraltar where Norman was stationed. Whilst in Gibraltar they welcomed two daughters: Ethel (1933–2005) and Ann (1936–2020).

Caterham was widowed in 1976, but ever the optimist, she embraced this new chapter of life. She enjoyed gardening, walking her dogs, spending time with family, and socialising with friends. She drove until the age of 97 and remained a regular bridge player well into her centenarian years. Today, at 115, her favourite pastime is sitting in the sun in her garden — aptly named Ethel’s Garden — listening to the birds.

https://longeviquest.com/2025/04/worlds ... rson-ever/

[erowind]

Timestamp matters on this one, should start about 46min in.

[wjfox]

NewLimit lands $130m to advance epigenetic reprogramming platform

May 6, 2025

Longevity biotech NewLimit has raised $130 million in Series B funding to advance its mission to extend human healthspan through epigenetic reprogramming. Founded with the goal of developing medicines that increase the number of healthy years in human life, NewLimit initially anticipated a long multi-year trajectory toward tangible scientific progress. However, the company claims it has made recent breakthroughs that have accelerated its development timeline, which led to its decision to raise new capital.

“We founded NewLimit to develop medicines that add healthy years to each human life,” said the company in a statement. “Initially, we thought it would take many years to show progress toward this goal. We’re proud that our team achieved this milestone faster than we expected.”

NewLimit’s scientific strategy centers on targeting aging as the root cause of many major diseases, rather than addressing individual pathologies in isolation. Epigenetic reprogramming, its core technology, involves manipulating the epigenome – the system that controls which genes are active or inactive in a given cell type. With age, this epigenetic control system deteriorates, leading to diminished cellular function and the onset of disease. By identifying transcription factor sets that can reset or rejuvenate these patterns, NewLimit seeks to restore youthful functionality to aged cells.

NewLimit has prioritized the immune system and liver as its first therapeutic areas. In preclinical studies, the company recently revealed it had restored ‘youthful function’ to liver and immune cells, discovering three transcription factor sets that demonstrate efficacy in animal models of liver disease and another three that rejuvenate aged T cells.

https://longevity.technology/news/newli ... -platform/

[weatheriscool]

Natural molecule reverses age- and dementia-related cognitive decline
By Paul McClure
May 14, 2025

https://newatlas.com/aging/natural-mole ... e-decline/
In a new study, researchers identified a molecule produced by a particular type of brain cell that reversed the cognitive decline seen in both healthy aging and dementia. It provides a deeper understanding of the aging process and a potential target for future treatments.

Aging causes a decline in cognition, as does dementia, including Alzheimer’s disease (although the former is a natural process, the latter is pathological). For years, scientists have been investigating ways of reversing that decline, and there have been some promising discoveries.

In a new study, a collaboration between the Federal University of Rio de Janeiro (UFRJ) and the University of São Paulo (USP) in Brazil, researchers examined the impact of hevin, a molecule secreted by star-shaped brain cells called astrocytes, on cognitive decline in older mice with and without dementia.

[wjfox]

Feelings of frailty can set in at 40

Thu 15 May 2025

Loneliness, feeling older than your age and a negative attitude to ageing are all associated with early stages of frailty, even in people as young as 40, new research can reveal.

Lead author Tom Brennan from Flinders University’s Caring Futures Institute says the study highlights an important intervention point that could help to prevent the progression of frailty later in life.

“Many people assume frailty is something that happens when we get much older,” said Mr Brennan, a PhD Candidate, “but our research shows the psychological and behavioural warning signs can emerge decades earlier, in people in their 40s, 50s, and 60s.

“For example, feeling older than you are might sound like a throwaway comment, but it turns out it can be a sign that something’s not quite right.

“With the impact frailty has on our healthcare system, alongside our growing ageing population, it’s important we investigate ways to slow its progression.”

Usually associated with older age, frailty is a recognised medical condition, marked by reduced strength, energy, and ability to recover from illness.

https://www.scimex.org/newsfeed/feeling ... t-in-at-40

[wjfox]

[wjfox]

New therapy aims to make muscles "more youthful"

21st May 2025

A novel treatment could restore muscle strength, offering hope for those with degenerative conditions and age-related muscle loss.

Read more: https://www.futuretimeline.net/blog/202 ... uthful.htm

[weatheriscool]

Anti-aging: Vitamin D shaves three years off your biological age
By Bronwyn Thompson
May 21, 2025

https://newatlas.com/aging/vitamin-d-anti-aging/
Taking a vitamin D supplement – or getting enough of the compound naturally – can knock three years off your biological aging, according to the results of a large, long-term study. This may not seem like a lot, over a lifetime, but it's a significant amount as you become more and more susceptible to age-related diseases.

Co-led by researchers at Mass General Brigham and the Medical College of Georgia, the The VITamin D and OmegA-3 TriaL (VITAL) study enrolled 25,871 US males aged 50 years and older and females aged 55 years and older to study a range of health biomarkers potentially impacted by both omega-3 and vitamin D supplementation. A subset of 1,054 participants featured in the VITAL Telomere study, where this biological aging marker was the focus.

What they found was that, when assessed at baseline and then again after two and then four years, the subset of participants who had been receiving vitamin D3 (2,000 IU/day) had significantly longer telomeres within their white blood cells than those receiving a placebo. (Omega-3 fatty acid had no effect on this health biomarker.)

[weatheriscool]

Common diabetes drug associated with “exceptional longevity”
By Paul McClure
May 24, 2025
https://newatlas.com/aging/metformin-di ... longevity/

Metformin, a drug used as a first-line treatment for type 2 diabetes, has been associated with a 30% lower risk of death, according to a new study. The research adds to the growing body of evidence suggesting that the common drug may possess anti-aging properties.

For decades, the drug metformin has been a first-line treatment for type 2 diabetics who can’t control their blood sugar through diet and exercise alone. In recent years, research has shown that the drug’s health-promoting properties extend beyond diabetes, including decreasing dementia risk and reducing osteoarthritic knee pain.

Now, a new study led by the University of California, San Diego (UC San Diego) has found that metformin use by women with type 2 diabetes was associated with “exceptional longevity,” which is defined as living to advanced ages such as 90 and older.

Metformin is known to activate FOXO3, a gene that has been strongly implicated in aging processes and longevity. It’s involved in regulating the cellular response to stress, such as oxidative stress, a key factor in aging. It activates genes that enhance cell survival and resistance to programmed cell death or apoptosis. And it’s involved in the regulation of DNA repair mechanisms.

[wjfox]

Anti-Aging Cocktail Extends Mouse Lifespan by About 30 Percent

28 May 2025

Scientists in Europe have tested an anti-aging drug cocktail in mice and found that it extended the animals' lifespans by around 30 percent. The mice stayed healthier for longer too, with less chronic inflammation and delayed cancer onset.

The two drugs are rapamycin and trametinib, which are both used to treat different types of cancer. Rapamycin is also often used to prevent organ rejection, and has shown promise in extending lifespans in animal tests. Trametinib, meanwhile, has been shown to extend the lifespan of fruit flies, but whether that worked in larger animals remained to be seen.

So for a new study, a research team led by scientists from the Max Planck Institute in Germany investigated how both drugs, on their own and together, could extend lifespan in mice.

True to its reputation, rapamycin alone was found to extend the lifespan of mice by 17 to 18 percent. Trametinib wasn't too bad either, boosting longevity by 7 to 16 percent. But when their powers combined, treated mice saw a significant lifespan extension of around 26 to 35 percent.

https://www.sciencealert.com/anti-aging ... 30-percent

[weatheriscool]

Anti-Aging Cocktail Extends Mouse Lifespan by About 30 Percent

28 May 2025

Scientists in Europe have tested an anti-aging drug cocktail in mice and found that it extended the animals' lifespans by around 30 percent. The mice stayed healthier for longer too, with less chronic inflammation and delayed cancer onset.

The two drugs are rapamycin and trametinib, which are both used to treat different types of cancer. Rapamycin is also often used to prevent organ rejection, and has shown promise in extending lifespans in animal tests. Trametinib, meanwhile, has been shown to extend the lifespan of fruit flies, but whether that worked in larger animals remained to be seen.

So for a new study, a research team led by scientists from the Max Planck Institute in Germany investigated how both drugs, on their own and together, could extend lifespan in mice.

True to its reputation, rapamycin alone was found to extend the lifespan of mice by 17 to 18 percent. Trametinib wasn't too bad either, boosting longevity by 7 to 16 percent. But when their powers combined, treated mice saw a significant lifespan extension of around 26 to 35 percent.

https://www.sciencealert.com/anti-aging ... 30-percent

I wish these medicines would have studies done on humans. I am sure there's many thousands of people on them and there's no reason why data can't be taken.

This could be the lowest hanging fruit to the first anti-aging drugs.

[wjfox]

Taurine may not be a key driver of ageing after all

Taurine supplements have previously been found to extend the lifespan of monkeys and mice, but a new study in humans shows that the amino acid doesn’t decline with age

5 June 2025

The amino acid taurine was once thought to decline with age, and animal research suggested that taurine supplements could delay ageing. But a new study shows that the decline doesn’t happen consistently. In fact, taurine levels tend to increase in people over time, suggesting that low levels of the nutrient aren’t a driver of ageing.

https://www.newscientist.com/article/24 ... after-all/

[weatheriscool]

1,000 dogs & counting: Milestone achieved in life-extending drug trial
By Paul McClure
June 07, 2025
https://newatlas.com/pets/longevity-dru ... milestone/

In February 2024, when Boo the Whippet became the first patient in a clinical trial of a life-extending drug for senior dogs, a call was put out for more canines. A milestone was reached in the ongoing trial when 10-year-old Miniature Dachshund Winston became the thousandth dog to enrol.

Editor's note: Readers often ask us for follow-ups on memorable stories. What has happened to this story over the years? This article was originally published in February 2024 but has been re-edited and updated with new information current as of June 5, 2025. Enjoy!

The STAY study, a clinical trial testing the effectiveness of a life-extending drug, LOY-002, on senior dogs, is now well underway. Results from a trial of LOY-001, the drug's predecessor, which was made for large-breed dogs, were so encouraging that they paved the way for Loyal, the biotech company that makes the drug, to start a new trial for dogs of nearly every size.

[weatheriscool]

[weatheriscool]

Anti-aging drug as good for cell health as dieting or fasting
By Bronwyn Thompson
June 18, 2025
https://newatlas.com/aging/anti-aging-drug-diet/

A large meta-analysis has found that the drug leading the charge in anti-aging science is just as effective in protecting cells and cognitive function as cutting calories or intermittent fasting (IF). It's the most comprehensive study of rapamycin yet.

In the largest study of its kind, researchers from the University of East Anglia (UEA) and the University of Glasgow looked at 167 studies conducted on lifespan-extending therapies on eight different vertebrates – including primates, rodents and fish – to see how rapamycin compared to traditional methods of healthy aging like cutting calories or fasting.

"Dietary restriction – for example through intermittent fasting or reduced calorie intake – has been the gold standard for living longer," said co-lead researcher Dr Zahida Sultanova, from UEA’s School of Biological Sciences. "But it’s difficult for most of us to maintain long-term.

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan

Suppression of the insulin–IGF–mTORC1–Ras network ameliorates aging in animals. Many drugs have targets in the network because of its roles in cancer and metabolic disease and are candidates for repurposing as geroprotectors. Rapamycin, an established geroprotective drug, blocks mTORC1 signaling, and trametinib inhibits the Ras–MEK–ERK pathway. In this study, we assessed survival and health of male and female mice treated with trametinib, rapamycin or their combination.

https://www.nature.com/articles/s43587-025-00876-4

Wjfox needs to get on this stuff for a few decades to slow his aging down. I could see a pill of this being given at a high dose may extend life and may be our first anti-aging pill.

[firestar464]