Aging & Longevity News and Discussions

[wjfox]

This doesn't sound very convincing to me.

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Ageing process is unstoppable, finds unprecedented study

Thu 17 Jun 2021 12.37 BST

Immortality and everlasting youth are the stuff of myths, according to new research which may finally end the eternal debate about whether we can live for ever.

Backed by governments, business, academics and investors in an industry worth $110bn (£82.5bn) – and estimated to be worth $610bn by 2025 – scientists have spent decades attempting to harness the power of genomics and artificial intelligence to find a way to prevent or even reverse ageing.

But an unprecedented study has now confirmed that we probably cannot slow the rate at which we get older because of biological constraints.

The study, by an international collaboration of scientists from 14 countries and including experts from the University of Oxford, set out to test the “invariant rate of ageing” hypothesis, which says that a species has a relatively fixed rate of ageing from adulthood.

“Our findings support the theory that, rather than slowing down death, more people are living much longer due to a reduction in mortality at younger ages,” said José Manuel Aburto from Oxford’s Leverhulme Centre for Demographic Science, who analysed age-specific birth and death data spanning centuries and continents.

https://www.theguardian.com/science/202 ... nted-study

[raklian]

This doesn't sound very convincing to me.

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Ageing process is unstoppable, finds unprecedented study

Even if it's true, it doesn't change the fact we still can repair the damage caused by the various processes that cause aging. That's why they call it "engineered negligible senescence."

None of the ant-aging proponents claimed the aging process can be stopped.

[wjfox]

[wjfox]

[wjfox]

[raklian]

40% is very significant. Whether it will translate to humans remains to be seen, but if it's possible to extend the lifespan of a mammal by 40%, this opens up many avenues to longevity interventions that weren't possible just few years ago. If these results translate to humans, there is a chance our generation will get to live to 120s if we choose to undergo this treatment.

Things are starting to accelerate when respect to anti-aging rejuvenations. Maybe we should adopt something like Moore's Law but for measuring the increases to lifespans in time intervals.

[Ken_J]

Maybe we should adopt something like Moore's Law but for measuring the increases to lifespans in time intervals.

isn't that what the longevity escape velocity is? Literally measuring the years extended per year of time passing. with a point at which less than a year goes by between years added.

[wjfox]

Small sample size, and yet to be peer-reviewed, but a 40% increase would be huge. Equivalent to human lifespan increasing from 80 to ~112.

[raklian]

Small sample size, and yet to be peer-reviewed, but a 40% increase would be huge. Equivalent to human lifespan increasing from 80 to ~112.

There was a commentary by another longevity researcher who isn't part of this study saying this news is significant. It's not exactly a proper peer-review but more like a tentative thumbs up.

[Yuli Ban]

Harvard Scientists Pinpoint ‘Ground Zero’ of Aging in Mouse Embryo Study

How do old cells in adult humans give rise to the youthful cells found in infants? New research suggests they reset to their lowest biological age in early embryonic development, with potential ramifications for longevity science.

For a long time, it was assumed that germline cells—those that form eggs and sperm and pass a parent’s genetic information on to their children—were essentially ageless. But how this could be was never clear and more recent research had shown that germline cells do accumulate the signs of aging.

This led to the conclusion that there must be some kind of rejuvenation event that allows the offspring’s cells to start with a clean slate. But when and how this occurs was a mystery.

Now a team from Harvard has shown that the age of mouse embryo cells resets about a week into development, representing the “ground zero” of aging. The finding not only provides insight into the fundamental dynamics of aging, but also suggests we might mimic the process in adult cells to rejuvenate aging tissues.

[wjfox]

[R8Z]

Is anyone here already taking supplements or in a different diet with aging in mind? I'd love to hear recommendations on what I could start doing right NOW and not wait for a wonder drug from the future (although my expectation for it is immense).

I am already doing intermittent fasting, exercising (almost daily) and taking supplementary vitamins but nothing other than this.

[wjfox]

Is anyone here already taking supplements or in a different diet with aging in mind? I'd love to hear recommendations on what I could start doing right NOW and not wait for a wonder drug from the future (although my expectation for it is immense).

I am already doing intermittent fasting, exercising (almost daily) and taking supplementary vitamins but nothing other than this.

I used to drink quite frequently, but almost never drink now. For many years, I heard about the supposed benefits of red wine, but then I kept seeing more and more studies claiming any amount of alcohol has a net negative effect in terms of aging. So I only drink on rare/special occasions now.

I've also completely given up sugary drinks, for many years now. So I almost never drink coke, orange squash, etc. and instead have green tea, peppermint tea, a few other herbal teas. Green tea is one of the absolute healthiest things you can drink, from what I've read. It literally repairs and restores damaged DNA. It has multiple benefits in terms of cancer and heart health. So I drink as much of that stuff as possible. I also have 2 or 3 coffees each morning, which is now proven in multiple scientific studies to protect your liver. Plus, I always have low-fat milk with my coffee. Milk is good for bone strength.

In terms of foods – I usually stick to salads, and low-calorie meals. Almost never eat red meat. Lots of lettuce, cucumber, and a couple of oily fish high in omega 3 (i.e. salmon) each week. Minimal amounts of dark chocolate (four of those little squares from Lindt, each day, is apparently good for you).

Also, something that Starspawn recommended in the previous forum is pomegranate seeds. So I've been adding those to my weekly shop for the last couple of years. They have a slightly unpleasant texture, so I always mix them with yoghurt. The seeds apparently have remarkable anti-aging properties and, like green tea, are one of the healthiest things you can consume.

Food and drink aren't the only things you should focus on, of course. Exercise and good sleep are really important too. I have a treadmill in my studio and always try to do the minimum 150 minutes of recommended exercise per week, and sometimes do a lot more (200-300 minutes). If you have trouble sleeping then I recommend avoiding a computer, TV, or phone screen for at least 1 hour before bed. If you still have insomnia then get the book and CD by Paul McKenna, "I can make you sleep", which is awesome and really does work.

Finally – it's vital to stay active, and interested in the world around you, maintain a good support network and social connections, establish a good work-life balance and enough time for relaxation. Loneliness can be almost as bad as smoking, drinking, obesity, etc. Find hobbies, local groups to join and meet people, develop your self-confidence and a positive attitude. Don't worry about the future, and don't dwell on the past, but instead focus on enjoying the here and now.

[Ken_J]

Is anyone here already taking supplements or in a different diet with aging in mind? I'd love to hear recommendations on what I could start doing right NOW and not wait for a wonder drug from the future (although my expectation for it is immense).

I am already doing intermittent fasting, exercising (almost daily) and taking supplementary vitamins but nothing other than this.

Had a thread on the last iteration of the forum for discussion of things like that, and started one here viewtopic.php?f=9&t=605 if you'd like.

[weatheriscool]

Antiaging Gene Therapies Extend Lifespan of Mice by 41%
July 1, 2021 by Brian Wang

Antiaging gene therapies to overexpress TERT and Follistatin were used in a mouse model. The mice saw a 41 and 32% increase in median life span. The study also used a novel viral vector, cytomegalovirus for the delivery.

Liz Parish of Bioviva has treated herself with all of these antiaging gene therapies.

If humans experienced the same antiaging effect as the mice then humans would live to a median age of 100 with these treatments.

Biorxiv preprint – New intranasal and injectable gene therapy for healthy life extension

https://www.nextbigfuture.com/2021/07/a ... by-41.html

[wjfox]

[Ken_J]

https://www.eurekalert.org/pub_releases ... 4piT8TPm2E

Castration delays DNA aging

[wjfox]

https://www.eurekalert.org/pub_releases ... 4piT8TPm2E

Castration delays DNA aging

Think I'll pass on that.

[weatheriscool]

Off-Patent Osteoporosis Drug Also Found to Extend Lifespan
July 8, 2021 by Brian Wang

Zoledronate is a biophosphonate, a drug used to strengthen bones and reduce the risk of osteoporosis-related bone fractures. It is well-absorbed into the bones, so it only needs to be administered through infusion once a year.

A 2010 study had found that people who were given zoledronate after experiencing hip fractures showed slightly reduced all-cause mortality compared to a control group. Patients who took the drug were at significantly lower risk for heart arrhythmias and pneumonia.

https://www.nextbigfuture.com/2021/07/o ... espan.html

[raklian]

Who knew cryptocurrencies would be part of the solution that will help Aubrey de Grey with his mission of defeating aging.