I expect we'll start to seeing more robust anti-aging vaccines in the years to come. In a few decades, I predict governments will mandate anti-aging vaccines just like they do with vaccines against diseases today. The justification they will use is that those vaccines will tremendously reduce healthcare costs for geriatric care as well as the treatment of diseases that are highly correlated with the aging process.
A vaxx worth taking. Sign me up.
Seems he deleted the original, and then reposted as a reply elsewhere. I've edited my post with his (new) tweet, which contains the same graph.
A group of genes that play an essential role in building components of our cells can also impact human lifespan, finds a new study led by UCL researchers.
The genes have previously been found to extend lifespan in small organisms, such as making fruit flies live 10% longer, but this is the first time scientists have demonstrated a link in people as well, as they report in a new Genome Research paper.
Co-lead author Dr. Nazif Alic (UCL Institute of Healthy Ageing) said, "We have already seen from extensive previous research that inhibiting certain genes involved in making proteins in our cells, can extend lifespan in model organisms such as yeast, worms and flies. However, in humans, loss of function in these genes has been seen to cause diseases, such as developmental disorders known as ribosomopathies.
"Here, we have found that inhibiting these genes may also increase longevity in people, perhaps because they are most useful early in life before causing problems in late life."
The genes are involved in the protein synthetic machinery of our cells, which is essential for life, but the researchers say it may be that we do not need as much of its effect late in life. The genes appear to be an example of antagonistic pleiotropy, where genes that shorten our lives are selected for in evolution if they help us early in life and through our child-bearing years.
The researchers reviewed genetic data from previous studies involving 11,262 people who had lived an exceptionally long life, to an age above the 90th percentile of their cohort. They found that people with reduced activity of certain genes were more likely to live very long lives. The genes are linked to two RNA polymerase enzymes (Pols) that transcribe ribosomal and transfer RNAs, namely Pol I and Pol III, as well as the expression of ribosomal protein genes.
Age may be just a number, but it's a number that often carries unwanted side effects, from brittle bones and weaker muscles to increased risks of cardiovascular disease and cancer. Now, scientists at the Salk Institute, in collaboration with Genentech, a member of the Roche group, have shown that they can safely and effectively reverse the aging process in middle-aged and elderly mice by partially resetting their cells to more youthful states.
"We are elated that we can use this approach across the life span to slow down aging in normal animals. The technique is both safe and effective in mice," says Juan Carlos Izpisua Belmonte, co-corresponding author and a professor in Salk's Gene Expression Laboratory. "In addition to tackling age-related diseases, this approach may provide the biomedical community with a new tool to restore tissue and organismal health by improving cell function and resilience in different disease situations, such as neurodegenerative diseases."
As organisms age, it is not just their outward appearances and health that change; every cell in their bodies carries a molecular clock that records the passage of time. Cells isolated from older people or animals have different patterns of chemicals along their DNA—called epigenetic markers—compared to younger people or animals. Scientists know that adding a mixture of four reprogramming molecules—Oct4, Sox2, Klf4 and cMyc, also known as "Yamanaka factors"—to cells can reset these epigenetic marks to their original patterns. This approach is how researchers can dial back adult cells, developmentally speaking, into stem cells.
Findings could lead to targeted approach for treating aging.
Research from the Babraham Institute has developed a method to ‘time jump’ human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function. Work by researchers in the Institute’s Epigenetics research program has been able to partly restore the function of older cells, as well as rejuvenating the molecular measures of biological age. The research is published today (April 7, 2022) in the journal eLife and whilst at an early stage of exploration, it could revolutionize regenerative medicine.
What is regenerative medicine?
As we age, our cells’ ability to function declines and the genome accumulates marks of aging. Regenerative biology aims to repair or replace cells including old ones. One of the most important tools in regenerative biology is our ability to create ‘induced’ stem cells. The process is a result of several steps, each erasing some of the marks that make cells specialized. In theory, these stem cells have the potential to become any cell type, but scientists aren’t yet able to reliably recreate the conditions to re-differentiate stem cells into all cell types.
Scientists have developed a promising new method to combat the age-related losses in muscle mass that often accompany immobility after injury or illness. Their technique, demonstrated in mice, arrests the process by which muscles begin to deteriorate at the onset of exercise after a period of inactivity.
They report their findings in the Journal of Physiology.
Exercise, particularly engagement in load-bearing activities, helps retain muscle mass—and is particularly important as one ages, said Marni Boppart, a professor of kinesiology and community health at the University of Illinois Urbana-Champaign who led the research. Injury or illness can lead to periods of immobility and declines in muscle quality.
"When we're not able to contract the muscle, it is going to atrophy," Boppart said. "If that immobility continues for very long, there's going to be significant loss of muscle mass and strength."
By Lucy Craft
April 18, 2022 / 7:15 AM / CBS News
Tokyo – This month, a team of researchers at Osaka University declared an experimental treatment involving four patients suffering from corneal disease a success. The patients, who ranged in age from their 30s to 70s, received transplanted stem cells grown in the lab, known as iPS cells. Three had improved sight, and all were free of side effects one year later.
"This could be a revolutionary treatment that could overcome the challenges that existing treatment has faced, such as a shortage of cornea donors or transplant rejection," Koji Nishida, an Osaka University professor of ophthalmology, said at a news conference.
It was the latest in a flurry of iPS-related announcements in Japan as the country tries to carve a niche in "regenerative medicine" by culturing healthy cells to replace diseased, injured or non-functioning ones.
The world’s oldest person, Japan’s Kane Tanaka, has died at 119 years of age, authorities of Japan’s Fukuoka prefecture confirmed to EFE on Monday.
Born on Jan. 2, 1903 in the old village of Wajiro, which is now part of the city of Fukuoka on the southern island of Kyushu, Tanaka died in a hospital in the city on Apr. 19 at the age of 119 years and 108 days.
Tanaka lived through five different Japanese eras (Meiji, Taisho, Showa, Heisei and today’s Reiwa) and had set herself a goal of turning 120 next year, according to her family.
She was recognized by the Gerontology Research Group and the Guinness World Record as the oldest woman and the oldest person in the world in 2019.
At the age of 19 she married, and the family got ahead running udon noodle restaurants.
the skincell story is actually very good news. the revitalization of healing and collagen production (even if only partial) has huge potential for other cell groups like arteries and digestive systems. People don't realize how structurally important collagen is to many organs and systems of the body, and it's decline is a factor in a lot of aging related sickness and injury.
Since time machine technology is not currently available this will have to do. Time is still at the moment the only non refundable receipt you cannot take back so life extension technology like this is always helpful and I am grateful for!
