Aging & Longevity News and Discussions

[wjfox]

^ Could somebody please ELI5 what this actually means, and what will happen?

[raklian]

^ Could somebody please ELI5 what this actually means, and what will happen?

Aubrey de Grey is referring to this fundraising effort using a special kind of cryptocurrency which is being handled by Richard Heart, the founder of the HEX cryptocurrency of which the PulseChain is based on. Here's the website - https://pulsechain.com/

Here's an excerpt from the website's page that outlines the fundraising effort for SENS:



It's a game-changer because the more people invest in this crypto, more they get rewarded as you see is explained above. The crypto market is worth trillions. A large portion of that value is from people who live paycheck to paycheck seeking a way to enrich their own lives with cryptocurrencies. You can guess as to what the implications are.

Also, I conclude with a link to a page on SENS' website regarding this fundraising effort:

https://www.sens.org/pulse-chain-airdrop/

It does clarify some aspects that are confusing to a lot of people about how cryptocurrencies are involved in this.

An airdrop is basically sending a cryptocurrency in any amount to a wallet address with the intention of giving it away (there are also other reasons).

[wjfox]

[Ken_J]

looks like an ounce of tuna, or half a quart of milk, all beat 1 pound of chicken or turkey in meeting your daily tryptophan needs. cheeses, oats, nuts, chocolate and some fruits can all be sources of triptophan.

[aducknamedjoe]

Interestingly some research on tryptophan restriction in rats indicates it may have a pro-aging effect (restriction increased lifespan): https://pubmed.ncbi.nlm.nih.gov/22255/

Though this possibly could be related to protein since protein restriction has also shown some life-extending effects (though the science there seems pretty complex as well): https://www.longevityadvice.com/protein-aging/

[weatheriscool]

Scientists reverse age-related memory loss in mice
https://medicalxpress.com/news/2021-07- ... -loss.html

Scientists at Cambridge and Leeds have successfully reversed age-related memory loss in mice and say their discovery could lead to the development of treatments to prevent memory loss in people as they age.

In a study published today in Molecular Psychiatry, the team show that changes in the extracellular matrix of the brain - 'scaffolding' around nerve cells—lead to loss of memory with aging, but that it is possible to reverse these using genetic treatments.

Recent evidence has emerged of the role of perineuronal nets (PNNs) in neuroplasticity—the ability of the brain to learn and adapt—and to make memories. PNNs are cartilage-like structures that mostly surround inhibitory neurons in the brain. Their main function is to control the level of plasticity in the brain. They appear at around five years old in humans, and turn off the period of enhanced plasticity during which the connections in the brain are optimized. Then, plasticity is partially turned off, making the brain more efficient but less plastic.

[raklian]

The Rising Importance of Crypto in Aging Research

https://www.lifespan.io/news/the-rising ... -research/

The landscape of research funding and investment is changing, particularly with the influx of interest from the crypto community in the last year or two. A lot of people in this community are software engineers, coders, programmers, and other Silicon Valley types, and many of them have an interest in life extension.

[weatheriscool]

Preclinical study finds success in reversing age-related memory loss
By Rich Haridy
July 22, 2021
https://newatlas.com/science/method-rev ... onal-nets/

An intriguing new study from researchers in the United Kingdom is proposing an innovative method to treat age-related memory loss. The preclinical research shows memory decline in aging mice can be reversed by manipulating the composition of structures in the brain known as perineuronal nets.

Perineuronal nets (PNNs) are structures in the brain that envelop certain subsets of neurons, helping stabilize synaptic activity. They essentially put the brakes on the neuroplasticity seen in the first few years of life.

[Yuli Ban]

[erowind]

.

[weatheriscool]

Higher Levels of Omega-3 in the Blood Increase Life Expectancy by Almost Five Years
https://scitechdaily.com/higher-levels- ... ive-years/
A 1% increase in this substance in the blood is associated with a change in mortality risk similar to that of quitting smoking.

Levels of omega-3 fatty acids in the blood are as good a predictor of mortality from any cause as smoking, according to a study involving the Hospital del Mar Medical Research Institute (IMIM), in collaboration with The Fatty Acid Research Institute in the United States and several universities in the United States and Canada. The study, published in The American Journal of Clinical Nutrition, used data from a long-term study group, the Framingham Offspring Cohort, which has been monitoring residents of this Massachusetts town, in the United States, since 1971.

Researchers have found that omega-3 levels in blood erythrocytes (the so-called red blood cells) are very good mortality risk predictors. The study concludes that “Having higher levels of these acids in the blood, as a result of regularly including oily fish in the diet, increases life expectancy by almost five years,” as Dr. Aleix Sala-Vila, a postdoctoral researcher in the IMIM’s Cardiovascular Risk and Nutrition Research Group and author of the study, points out. In contrast, “Being a regular smoker takes 4.7 years off your life expectancy, the same as you gain if you have high levels of omega-3 acids in your blood,” he adds.

2,200 people monitored over eleven years The study analyzed data on blood fatty acid levels in 2,240 people over the age of 65, who were monitored for an average of eleven years. The aim was to validate which fatty acids function as good predictors of mortality, beyond the already known factors. The results indicate that four types of fatty acids, including omega-3, fulfill this role. It is interesting that two of them are saturated fatty acids, traditionally associated with cardiovascular risk, but which, in this case, indicate longer life expectancy. “This reaffirms what we have been seeing lately,” says Dr. Sala-Vila, “not all saturated fatty acids are necessarily bad.” Indeed, their levels in the blood cannot be modified by diet, as happens with omega-3 fatty acids.

These results may contribute to the personalization of dietary recommendations for food intake, based on the blood concentrations of the different types of fatty acids. “What we have found is not insignificant. It reinforces the idea that small changes in diet in the right direction can have a much more powerful effect than we think, and it is never too late or too early to make these changes,” remarks Dr. Sala-Vila.

The researchers will now try to analyze the same indicators in similar population groups, but of European origin, to find out if the results obtained can also be applied outside the United States. The American Heart Association recommends eating oily fish such as salmon, anchovies or sardines twice a week because of the health benefits of omega-3 acids.

Reference: “Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort” by Michael I McBurney, Nathan L Tintle, Ramachandran S Vasan, Aleix Sala-Vila and William S Harris, 16 June 2021, The American Journal of Clinical Nutrition. DOI: 10.1093/ajcn/nqab195

[andmar74]

Supercentenarian and remarkable age records exhibit patterns indicative of clerical errors and pension fraud

https://www.biorxiv.org/content/10.1101/704080v2

[wjfox]

[andmar74]

Sinclair looks amazing at 52..

[raklian]

Sinclair looks amazing at 52..

Whatever he's doing to increase his longevity (or healthspan for the matter) seems to be working.

[andmar74]

https://www.fightaging.org/archives/202 ... life-span/

It is Plausible that Continual Removal of Senescence Cells Would Impair Regeneration and Limit Benefits to Life Span

[wjfox]

[wjfox]

Senescence field has “completely exploded”

August 5, 2021

Aubrey de Grey expects senescence-targeting sector will see Phase 3 trials within “a couple of years”.

https://www.longevity.technology/senesc ... -exploded/

[wjfox]

[raklian]

Maybe much ado about nothing?