Naked mole-rats have the longest life span among all rodents and can resist aging and the age-related diseases. However, the precise mechanisms underlying this ability are largely unclear.
In a new study, Japanese researchers have identified a unique species-specific "natural senolytic" or senescent cell-removal mechanism in NMRs, involving serotonin metabolism and the INK4a-RB signaling axis. Their findings provide useful insights into ways to resist aging and age-related diseases, including cancer. The study is published in The EMBO Journal.
Heterocephalus glaber or naked mole-rats (NMRs)—a mammal species native to Eastern Africa—are the longest-living rodents with an exceptionally long lifespan of over 37 years with a unique ability to delay aging and resist age-related diseases, such as cancer. For these reasons, NMRs have attracted a lot of attention, with researchers hoping to unravel the mechanisms contributing to their longevity.
You Are Likely To Live Longer Than You Think: Day Three Of The 10th ARDD Meeting Featuring Dr. David Sinclair
The day's most anticipated event was David Sinclair's lecture on "Epigenetic Stabilization and Reprogramming: An Update." The talk was so compelling that the venue reached maximum capacity, and the online audience was so large that it briefly overwhelmed the AV system. Sinclair's presentation was a masterclass in the information theory of aging and epigenetic reprogramming, topics at the cutting edge of longevity research. His exit was akin to that of a rockstar, as he had to leave immediately after his talk for another engagement, avoiding a throng of autograph-seeking graduate students. He was accompanied by a famous longevity physician, Dr. Serena Poon, who helped curate his meetings and limited access for some of the supplement and wellness vendors who often abuse pictures with Dr. Sinclair to promote their practices.
New Study in Nature Aging: Reversing Aging in the Blood Stem Cells and the Immune System September 6, 2023
Introduction:
(From Researchers of the University of Lausanne (UNIL), the Lausanne University Hospital (CHUV) and the Ludwig Institute for Cancer Research, in Switzerland via Eurekalert) As we age, our bodies face numerous challenges, including a decline in immune system function and an increased vulnerability to various health issues. An innovative study has recently shed light on these challenges and unveiled a potential solution that could have far-reaching implications for aging individuals.
The Role of Hematopoietic Stem Cells in Immune Function
The aging process is often accompanied by a decline in the proper functioning of the hematopoietic and immune systems, making older adults more susceptible to infections, blood disorders, and even tumor development.
The study* published on August 31st, 2023 in the journal Nature Aging, led by Nicola Vannini, group leader in the Department of oncology UNIL-CHUV in Lausanne (CH) and member of the Lausanne branch of the Ludwig Institute for Cancer Research, focused on a key player in the blood system – hematopoietic stem cells (HSCs). These cells are responsible for generating various types of blood cells, playing a critical role in maintaining a healthy immune system. As we age, HSCs experience a decline in their ability to regenerate blood and show a preference for a specific type of cell lineage, which contributes to immune system dysfunction.
Unveiling the Mitochondrial Connection
However, the researchers discovered a remarkable solution. By introducing a naturel compound called Urolithin A, which targets mitochondria – the energy powerhouses of cells – they were able to reverse the decline in HSC function. Mitochondria abnormalities were identified as a contributing factor to the aging of HSCs. Urolithin A acted as a mitochondrial modulator, effectively restoring the mitochondrial function within HSCs.
Urolithins are not found in food; however, their precursors are. Urolithin A is the result of transformation of ellagic acids and ellagitannins by the gut microflora in humans. Ellagitannins are found in pomegranates, nuts, some berries.
That's more plausible than Peter's insistence that we'll achieve it by 2030 or sooner. But still, 2038 seems pretty optimistic, even with AI intervention.
P.S. Just going back over this thread. Jesus, so much interesting stuff that I keep missing, as I don't have time to read every thread! Will have to pay more attention to this one.
If our fda and republican party has their way then good luck getting such a drug to the market. If they win next year I wouldn't be shocked to see them ban anti-aging along with most vaccines. These people are fucking nuts. This doesn't mean that such won't be developed in other places like china, india or some other place in europe.
America is following the UK down the crapper.
My opinion is 2050 if republicans don't ban your ability to get it.
Harvard’s George Church has been involved in starting many successful biotech companies. In 1984, he developed the first direct genomic sequencing method, which resulted in the first genome sequence (the human pathogen, H. pylori). He helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. George invented the broadly applied concepts of molecular multiplexing and tags, homologous recombination methods, and array DNA synthesizers. His many innovations have been the basis for a number of companies including Editas (Gene therapy); Gen9bio (Synthetic DNA); and Veritas Genetics (full human genome sequencing).
Rejuvenate Bio is one his companies that has completed some clinical trials of combination gene therapy to treat age related diseases in dogs. They will soon start human clinical trials for combination gene therapy to treat age related diseases.
erowind wrote: ↑Fri Sep 29, 2023 10:15 am
I signed up for Tally Health's beta a while ago, David Sinclair's a co founder. On top of a quarterly age test they send you a cocktail of anti-aging supplements to take daily. Anyone here know if these are snake oil or legit?
Tally Health is legit in terms of being earnest in what they're doing but the question whether the cocktail actually works to reverse at least some aspects of aging by a statistically significant degree is another matter. Do you see any references or citations to studies proving their efficacy on the website somewhere?
To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
