Calorie Restriction Study Reveals Complexities in How Diet Impacts Aging April 17, 2024
Introduction:
(Eurekalert) UNIVERSITY PARK, Pa. — Penn State researchers may have uncovered another layer of complexity in the mystery of how diet impacts aging. A new study led by researchers in the Penn State College of Health and Human Development examined how a person’s telomeres — sections of genetic bases that function like protective caps at the ends of chromosomes — were affected by caloric restriction.
The team published their results in Aging Cell. Analyzing data from a two-year study of caloric restriction in humans, the researchers found that people who restricted their calories lost telomeres at different rates than the control group — even though both groups ended the study with telomeres of roughly the same length. Restricting calories by 20% to 60% has been shown to promote longer life in many animals, according to previous research.
Over the course of human life, every time a person’s cells replicate, some telomeres are lost when chromosomes are copied to the new cell. When this happens, the overall length of the cell’s telomeres becomes shorter. After cells replicate enough times, the protective cap of telomeres completely dissipates. Then, the genetic information in the chromosome can become damaged, preventing future reproduction or proper function of the cell. A cell with longer telomeres is functionally younger than a cell with short telomeres, meaning that two people with the same chronological age could have different biological ages depending on the length of their telomeres.
caltrek: It is very frustrating when studies come up with such inconclusive results (see the rest of the article regarding how the study is inconclusive). Still, it is not surprising given the complexity of human biology.
When food is more expensive, it encourages (some people) eating less.
I just can't justify buying lots of food when I look at the prices. I' ve always found paying for a video game much more cost-effective than paying for food which disappears quickly and it seems like a waste. Also in an ecological sense. So much packaging for modern food!
Global economy doubles in product every 15-20 years. Computer performance at a constant price doubles nowadays every 4 years on average. Livestock-as-food will globally stop being a thing by ~2050 (precision fermentation and more). Human stupidity, pride and depravity are the biggest problems of our world.
Anti-aging biopharma company raises $40 million to begin human tests
By Paul McClure
April 24, 2024
“As people live longer, improving quality of life is paramount,” said Alex Morgan, a partner at Khosla Ventures, who chipped in to fund Rubedo’s first round of venture capital financing. “Rubedo is targeting senescent, or aging, cells that drive age-related disease. This first trial can bring us another step closer to achieving better healthspan.”
Senescent cells age and permanently stop dividing, but they don’t die. Over time, they accumulate in the tissues and release high levels of inflammatory chemicals and immune modulators that contribute to aging.
